We are located at the heart of Calabasas community providing Personalized and compassionate Cancer Care to over 1000 adults each year! Our commitment to the best in Cancer Care has improved lives of many who trust us with their treatment!
HHC is a partnership, made up of some of the most dedicated and kind hearted caregivers in the medical field! Healing humankind one patient at a time! Each of us, no matter our role, seek to treat each and every patient as we would a member of our own family!
What treatment options are available for Advanced Cancer Patients ?
Understanding treatment options are critical for advanced cancer patients.
There are 2 options for advanced cancer treatment
- Clinical Trial
- Standard Treatment
What is Clinical Trial ?
It is by way of Clinical Trials that new drugs are being developed!
Clinical trials are research studies that aim to find better ways to treat cancer. They test new drugs or treatment strategies to see if they are safe and effective. Clinical trials are specific tests designed to see how well new drugs or therapies work for a particular type of cancer. Each trial focuses on one kind of cancer and one specific medicine or treatment to make sure it’s effective and safe for people with that cancer.
Patients with cancer can choose to join these trials. It’s voluntary, and they can leave at any time. Patients who volunteer however, must meet specific participation criteria to join the trial. Only 1 out of 10 cancer patients are eligible to join clinical trials.
Clinical trials are crucial for advancing cancer treatment and offer patients the opportunity to receive new therapies that are not yet widely available. However, there is no guarantee of benefit, and there are risks involved. Even though treatments can help, they don’t always work, and there can be downsides. Often, the treatment might only work for a little while before it stops being effective. In some cases the body can become used to the medicine. When this happens, patients may need to look for other forms of treatments.
Which is why the decision to participate in a clinical trial should be made after a thorough discussion with your healthcare providers.
Our main goal is always to find the best and most effective treatment for you, and sometimes that could include looking into a clinical trial option. While our focus isn’t primarily on clinical trials, we’re open to considering them for certain patients when deemed necessary by your doctor. This means if there’s a chance that a clinical trial could be the right choice for your situation, we’ll think about it carefully.
What is Standard Treatment?
Most people who have advanced cancer are not able to join clinical trials. This includes around 9 out of 10 patients in this group. Instead, they need to follow established treatment plans that doctors commonly use.(NCCN Guidelines)
These treatments are chosen based on how far the cancer has progressed, which is known as the stage of cancer. Lower stages mean the cancer hasn’t spread much, while higher stages mean it has spread more.
The NCCN guidelines are a set of instructions that help doctors decide on the best way to treat different types of cancer. NCCN stands for National Comprehensive Cancer Network, which is a group made up of leading cancer centers. They create these guidelines based on the latest research to ensure that patients get the best care possible. The guidelines cover everything from how to find out what kind of cancer someone has, to what treatments should be used at every stage of the disease. They are updated regularly as new information and treatments become available.
So, for the majority of advanced cancer patients who can’t participate in clinical trials, doctors will look at how advanced the cancer is and consult the NCCN guidelines to determine the most appropriate standard treatment options.
Standard treatment protocols for cancer are like a one-size-fits-all plan. They are general methods that are used to treat all patients with a certain type and stage of cancer in the same way. However, this approach doesn’t take into account that every person’s body is different. People can react to treatments in various ways, and each person’s cancer can have unique characteristics. So, while these standard treatments can work well for many people, they might not be the best option for everyone because they don’t consider each person’s unique situation.
Another problem with standard cancer treatments is that they can become less effective over time. If the cancer comes back after treatment, which is known as a relapse, each time it might respond to the treatment for a shorter period than before.
Also, with each relapse, there’s a chance that the cancer cells will no longer respond to the medications you’ve used in the past, making them resistant. This means the drugs that used to work might not work anymore, and you might need to try different treatments
What is Precision Oncology or "The 3rd Option"?
Cancer care has evolved significantly over the years, transitioning from one-size-fits-all approaches to more personalized and precise treatments. Traditionally, cancer treatment involved standard protocols, primarily relying on chemotherapy, radiation, and surgery, often with significant side effects and varying degrees of efficacy. The effectiveness of these treatments largely depended on the cancer type and stage, with a generalized approach applied to all patients suffering from a similar form of cancer.
By understanding the genetic makeup of tumors, healthcare providers can now identify specific driver genes responsible for cancer growth and select therapies that target these genes. This method not only enhances the effectiveness of treatment but also minimizes unnecessary side effects.
We at Hope Health Center (HHC) are at the forefront of this paradigm shift in cancer care. We utilize advanced techniques such as next-generation gene sequencing to conduct comprehensive genetic studies on tumor samples. This enables us to customize treatment protocols for each patient, selecting the most effective combination of chemotherapy, immunotherapy, targeted therapy, and biological therapies. Such personalized care has shown remarkable success, even in patients who had previously failed standard treatments, offering new hope and improved quality of life to many.
This personalized approach is particularly crucial in treating advanced stages of cancer, where traditional methods may have limited impact. For example, by combining different FDA-approved medications based on individual tumor genetics and sensitivity, HHC provides what we call Precision Oncology or “The 3rd Option,” a unique strategy not widely practiced elsewhere. This integration of precision medicine in cancer care represents a significant leap forward, offering a more effective, patient-centered approach to combating this complex disease.
Why should you consider Precision Oncology or "The 3rd Option"?
At Hope Health center (HHC), we are redefining the approach to cancer care.
Why we do it?
Dr. Javadi’s fight against cancer is deeply personal, inspired by loss of his mother, Farideh, who bravely fought ovarian cancer. His journey is not just one of professional achievement but also a testament to the human spirit’s resilience in the face of adversity. At Hope Health Center, patients find not just a doctor, but an ally and advocate in their fight against cancer.
As your cancer specialist, Dr. Javadi’s goal is to learn how your tumor behaves. Then he uses medications to stop the tumor from growing, shrink it down, and hopefully get rid of it completely.
How we do it?
Understanding cancer is key to treating it effectively!
Think of cancer as a snake with lots of heads — if you get rid of one head, others can grow back. In the medical world, these heads are called “Mutations” and they help cancer cells grow. Our job as cancer specialists is to find these mutations and stop them with the right medications.
We use cutting-edge genetic tests, called Next Generation Genetic Sequencing (NGS), to find every mutation that could be causing your cancer to grow. Sometimes, your cancer may have many mutations, and that means we need to use several drugs to fight the cancer from multiple angles.
This approach is called multi-modality treatment, or Precision Oncology. It’s like a tailor-made suit; the treatment is customized just for you based on your genetic make up.
In precision Oncology, we target multiple mutations! The complete matching medications are
selected by your doctor based on their synergistic effects to attack your tumor from multiple angles.
we don’t just use one drug; we mix and match, combining Chemotherapy, Targeted therapy, Immunotherapy, and other treatments. This way, the treatment works better, is easier on the body(less side effects and less toxicity), and we hope to keep cancer away for a longer time(longer remission).
What makes Hope Health Center (HHC) different?
Many large cancer treatment centers have a limitation where they can use just one kind of treatment at a time. In other words, they can only target one mutation at a time!
For patients, this usually means use of standard protocols, primarily relying on chemotherapy, radiation, and surgery, often with significant side effects and varying degrees of efficacy. If Chemotherapy doesn’t work as hoped, the doctors will then try other treatments one by one. The effectiveness of these treatments largely depends on the cancer type and stage, with a generalized approach applied to all patients suffering from a similar form of cancer.
At the core of our treatment strategy is the application of advanced Next Generation Genetic Sequencing (NGS) to Identify specific driver genes responsible for cancer growth and select therapies that target these genes. The data derived from NGS lab results is processed by our state-of-the-art artificial intelligence, which perform over 4.5 million computations to identify synergistic medications to increase efficacy.
We don’t just use one drug; we mix and match Minimum Effective Doses, combining adjusted doses( low dose) of Chemotherapy, anti angiogenesis, Immunotherapy, and targeted therapy.
The underlying science of this treatment method is based on the principle of synergy within our biology, where used correctly, each drug significantly enhances the effectiveness of the others. Each agent in the Infusion Cocktail ( a word coined by Dr. Nader Javadi) has a specific role to play. One drug stops the flow of blood (Blood supply) to the cancer cells, which they need to survive and grow. Another strengthens your overall immune system so your body can fight the cancer better. And some others are responsible for preventing the growth of cancerous mutations. In other words, to help stop cancer cells from changing and growing out of control.
How effective is Precision Oncology?
It’s not uncommon for patients who choose precision oncology to feel a lot better soon after they begin their treatment. Many patients experience a marked improvement in their quality of life shortly after beginning treatment—sometimes in as little as one to two weeks.
Feeling less pain is a good sign that treatment is working well. For many advanced cancer patients life gets better when their pain gets less. In fact, many of our patients said their pain dropped by as much as 80% in the first two weeks of starting the treatment. Other common problems, like feeling out of breath, usually get better fast. Also, if cancer has spread and caused temporary paralysis, some patients see this improve too.
When our patients start to feel better, it’s not just a relief — it’s a strong sign that the treatment is successful and could help them live longer. Our treatment is designed to do more than just help you live longer. It’s about making every day better as you recover.
Patients who have tried this multipath targeted therapy have seen remarkable results, even those who didn’t do well with usual treatments before. They’re finding that they are getting better treatment response with fewer unpleasant side effects with better quality of life, it’s safer, and their cancer stays away for longer. These improvements are backed up by the latest research findings.
HHC is a private medical practice that stands out in the field of cancer treatment. We work closely with some of the best and most well-known genetic labs in the United States. This partnership allows us to look at the genetic factors influencing each patient’s cancer and to tailor treatments that are more effective and personal.
What really sets HHC apart is our use of artificial intelligence (AI). AI gives us an objective way to look at the data and support the decisions our doctors make about treatment plans. It’s like having a high-tech second opinion that helps ensure we’re choosing the best approach for each patient.
We’re among the very few cancer centers worldwide that have formed partnerships with leading AI technology firms. These collaborations are pushing the boundaries of what’s possible in cancer care. Dr. Javadi, our leading physician, brings his valuable front-line experience to the table as an advisor to some of the most innovative AI companies in healthcare. His insights help shape the future of medical AI, ensuring it meets the real-world needs of patients and doctors alike. With these efforts, HHC is at the forefront of
integrating cutting-edge technology and deep medical expertise to fight cancer more effectively.
Unlike many Cancer Centers, we at HHC have the ability to choose from a broader range of FDA-approved drugs, even for uses beyond what they were originally approved for. This means we can treat cancers in innovative ways, prescribing drugs ‘off-label’ when we believe they could be effective for a patient’s unique situation.
For example, let’s say there is a drug approved for treating a specific mutation in Cancer A. We’ve seen potential in this drug and might decide to use it in a smaller dose for treating Cancer B if we believe it could help.
However, it’s important to understand that while we are using our expertise to extend the potential benefits of these drugs, insurance companies may not always cover the cost for these off-label uses. They typically cover costs for the uses the FDA has specifically approved, like the original treatment for Cancer A. So, there’s a possibility that Insurance companies might not pay for the drug when it’s used for Cancer B, and this could affect the cost of the patient’s treatment. This capability enables us to tailor therapy to the unique needs of each patient, often with more favorable outcomes.
For patients receiving treatments at out U.S. HHC center, we offer a valuable resource: enrollment in patient assistance programs. Although we do not directly provide financial support, we leverage our established connections with various medical foundations to help make treatment more affordable. By doing so, we act as a bridge between patients and the financial resources they need, ensuring that financial concerns do not stand in the way of accessing vital, potentially life-saving therapies. Our role is to facilitate this process, guiding patients through the available options to reduce the financial burden of their treatment
Who is Eligible for Precision Oncology?
This initiative is especially pivotal for patients who:
- Patients with confirmed diagnosis of early Stage or advanced solid tumors(Patients with hematologic malignancies are not eligible)
- Have not seen improvements or have not responded to standard treatments.
- Are experiencing recurring, relapsed diseases.
If standard treatments haven't worked for a patient, can they try Precision Oncology instead?
Yes! A common problem with standard cancer treatments is that they can become less effective over time. If the cancer comes back after treatment, which is known as a relapse, each time the body might respond to the treatment for a shorter period than before.
When a patient gets a type of cancer treatment, we call it a ‘line’ of treatment.
The very first try at treatment, or the 1st ‘line,’ often has a good chance of working — about 50% of the time — and can keep the cancer away for a long stretch.
If the 1st line didn’t work and the patient experiences relapsed disease, a 2nd line of treatment is used. but it’s not usually as successful; it works for about 20% of patients and the results may not last as long.
The 3rd line has even lower success rates, around 5% to 0%, and sometimes it’s so tough on the body that patients can’t handle it.
However, there’s a brighter side for patients who opt for treatments that are customized for their specific situation. Even if the 1st treatment didn’t help, a personalized plan can improve their chances significantly. They could have up to a 75% chance of their cancer going into remission and staying away for a much longer time. Customized plans can really make a difference, offering hope when standard treatments haven’t worked well.
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